Telomere replication and germline immortality in C. elegans.

cAMP Signaling, Gene Regulation, alternative splicing, Cancer Cell Biology, Optical Imaging

Regulation of gene expression; control of oncogenesis and apoptosis.

Molecular genetics of blood vessel formation in mouse and zebrafish models.

Clinical adult and cancer genetics.

Mechanisms of chromosome segregation in yeast; chromosome and spindle dynamics.

Examination of problems in membrane trafficking and cell polarity using genetics

Mouse models of human disease, chromatin-modifying factors, epigenetics

Mechanisms of epigenetic regulation by long noncoding RNAs

Genetically engineered animal models in study of human disease

Heart development, mesodermal patterning, T box genes.

Regulation of DNA replication in mammalian cells.

Regulation of meiotic recombination in higher eukaryotes.

Molecular basis of Drosophila CNS development.

Viruses, Cancer Biology, Innate Immunity, Signal Transduction, Angiogenesis, and Transcription.

Plant disease resistance using Arabidopsis, innate immunity and cell-death control. Plant genomics. Bacterial pathogenesis and genomics, type III secretion systems

Mechanisms of transcription factor deregulation in cancer development

Oncogenes; ras superfamily protein; signal transduction

Anti-lymphoma therapies

Regulation of fat metabolism during development, aging, and disease

Three-dimensional genome architecture and gene regulation in development and disease

Gene expression and cell cycle control during development.

Cell cycle regulation by the ubiquitin system.

Molecular, cellular and bioinformatic dissection of the formation and function of transcriptional enhancers in cancer

Alternative splicing, epigenetic and intracellular trafficking in heart and skeletal muscle development and diseases

Cell cycle control, cytokinesis, and cell shape determination from fungi to mammals

Using C. elegans to discover fundamental mechanisms in cell and developmental biology

Development and evolution of the germ line stem cell niche.

Plant-pathogen interactions with a focus on bacterial virulence

HIV, transcription; electron microscopy

Genomic DNA transfer, drug-gene delivery and nanomedicine

Mechanisms of mammalian genome regulation, chemical biology and drug discovery

Identification and functional characterization of highly penetrant risk factors in neurodevelopmental disorders

Genetics of Arbovirus virulence and immune evasion

Integrative genomic characterization of cancer and precancer

Genetics, toxicants and nutrition: Role of gene-environment interactions in epigenetic gene regulation during development

Population genetics and evolution in Drosophila

Malaria drug resistance, diversity and population evolution

Genetics and genomics of environmentally-induced asthma

Molecular genetic analysis of hormone signaling in Arabidopsis.

Exploration of the role of hypoxia-inducible factor in tumorigenesis

Genetic and transcriptional mechanisms causing increased incidence of chronic pain and PTSD in women vs men following trauma exposure

Cytoskeleton-related mechanism in neuronal function and metabolism

Mitotic mechanisms and chromosome dynamics

the mechanisms of cell shape change

Genetics modeling of atheroscierosis in mice

Mammalian genetics; epigenetics; genomics

Regulation of RNA metabolism in animal cells

Mouse and fruitfly models of Spinal Muscular Atrophy

developmental genomics; regulation of gene expression

Transcriptional and epigenetic regulation of T cell differentiation during infection and cancer.

Human genetics and genomics; diabetes; complex diseases.

Modeling mechanisms of epigenetic and genomic heterogeneity that connect cancer driver mutations with malignant identity.

Plant developmental genetics and stem cell regulation

Systems genetics, genetics of complex traits, meiotic drive.

the biology of metastatic disease, which is responsible for the death of nearly all cancer patients

Cell adhesion; signal transduction and cancer.

Genomic and molecular classification of human tumors to guide therapy

Characterization and functional studies of dynamic DNA looping during monocyte differentiation in healthy individuals and in human disease, using genomics, genome editing, and bioinformatics.

Signal transduction in cancer and stem cells

Immunomodulatory mechanisms in pancreatic cancer and metastasis.

Regulation and function of altered chromatin remodeling complex activity.

V(D)J recombination; DNA double strand break repair

The Rau lab utilizes populations of mice to study the transcriptomic and epigenomic landscape underlying cardiovascular disorders using a combination of wet and dry-lab techniques

Plant development; auxin signaling; light responses

Functional genomics of cytoskeletal organization

Structure and function of DNA repair enzymes; biological clock

Genetic and molecular mechanisms of pain perception and opioid receptor function

Mechanisms of mitotic and meiotic recombination, double-strand break repair.

Genetics responses of immune cells to the gut microbiome; inflammatory bowel diseases (Crohn's disease, ulcerative colitis

Function and development of macrophages and brain microglia; regulation of inflammation and innate immune activation; genetic, genomic, cellular, and imaging approaches.

Roles of chromatin-modifying enzymes in developmental epigenetics and disease

Regulators of cytoskeletal dynamics

Context Specific Functions of Long Noncoding RNAs.

Genetic influences on brain structure and development

Histone modifications and gene regulation

T cells during normal and pathogenic hematolymphopoiesis

Retroviruses; molecular biology of AIDS virus

Genetic mapping of complex behavioral traits

Molecular epidemiological and translational studies of melanoma

Transcriptional regulation; inflammation and apoptosis; functional genomics; immunologic and neurologic diseases; chemotherapy; signal transduction and cell death

Epigenetic and transcriptional regulation in T cell differentiation, function and disease.

Integration of DNA replication and repair

epigenetics, gene regulation, and disease, notably hematopoietic malignancies

Regulation of G-protein-coupled receptor signal transduction pathways

Tumor suppressor genes; cancer genetics

Genetic regulation of T cell responses to virus infection.

asymmetric cell division in development and disease, epithelial differentiation

Genetic risk factors for neuropsychiatric illnesses & neurological mechanisms; genome folding in human brain by Hi-C

Our lab seeks to uncover the epigenetic mechanisms linking psychosocial stress with disease risk.

Genetics and mechanisms of cancer cell growth and division