May 10, 2017: Josh Lawrimore publishes paper in Molecular Biology of the Cell

Lawrimore_2017Josh Lawrimore (Kerry Bloom lab) published a paper titled “Microtubule dynamics drive enhanced chromatin motion and mobilize telomeres in response to DNA damage” in Molecular Biology fo the Cell (DOI: 10.1091/mbc.E16-12-0846). Image: Positioning of the telomere (green) within the nucleus; see paper for details.

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May 9, 2017: John Noto publishes review in RNA Biology

Noto_2017John Noto (Greg Matera lab) published a review titled “Engineering and expressing circular RNAs via tRNA splicing in RNA Biology (DOI: 10.1080/15476286.2017.1317911). Image: In vivo RNA circularization pathways; see article for details.

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May 9, 2017: Sarah Renner publishes paper in PLOS One

Renner_2017Sarah Renner (Jay Brenman lab) published a paper titled “Carbonic anhydrase III (Car3) is not required for fatty acid synthesis and does not protect against high-fat diet induced obesity in mice in PLOS One (DOI: 10.1371/journal.pone.0176502). Image: Alignment of cytosolic anhydrase sequences; see paper for details.

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May 9, 2017: Joe Durand publishes chapter in Adv. Protein Chemistry & Structural Biol.

Durand_2017Joe Durand (Al Baldwin lab) published a chapter titled “Targeting IKK and NF-κB for Therapy in Advances in Protein Chemistry and Structural Biology: Chromatin Proteins and Transcription Factors as Therapeutic Targets (DOI: 10.1016/bs.apcsb.2016.11.006). Image: Canonical and non-canonical NF-κB pathways; see article for details.

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May 5, 2017: Michaelyn Hartmann publishes review in Fly

Hartmann_2017Michaelyn Hartmann (Jeff Sekelsky lab) published an article titled “The absence of crossovers on chromosome 4 in Drosophila melanogaster: Imperfection or interesting exception? in Fly (DOI: 10.1080/19336934.2017.1321181). Image: Comparison of crossover rates on proximal 2L and 4; see article for details.

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May 5, 2017: Talia Hatkevich inducted into Frank Porter Graham Honor Society

Hatkevich_TaliaTalia Hatkevich (Jeff Sekelsky lab) was inducted into the Frank Porter Graham Graduate and Professional Student Honor Society. This award recognizes “outstanding service provided to the University and community by graduate and professional students.”  Professors Jeff Sekelsky and Greg Copenhaver were also inducted for “outstanding contributions to the development of graduate and professional education at the University.”

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April 6, 2017: Stephanie Bellendir and Danielle Rognstad publish paper in Nucleic Acids Research

SteBellendir2017phanie Bellendir (Jeff Sekelsky lab) and Danielle Rognstad (Jeff Sekelsky and Dorothy Erie labs) published an article titled “Substrate preference of Gen endonucleases highlights the importance of branched structures as DNA damage repair intermediates.” in Nucleic Acids Research (DOI: 10.1093/nar/gkx214). Image: Model for cleavage of Holliday junctions and flap substrates; see article for details.

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April 5, 2017: Mike Meers publishes paper in eLife

Mike MeerMeers2017s (Greg Matera lab) published an article titled “Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity” in eLife. (DOI: 10.7554/eLife.23249)  Image: Hex-plot heatmap plotting novel, unannotated transcription start sites by their location relative to the boundaries of the nearest gene and change in K36R; see article for details.

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April 5, 2017: Becky Bigler publishes paper in Scientific Reports

Bigler2017Becky Bigler (Anne Taylor lab) published an article titled “Messenger RNAs localized to distal projections of human stem cell derived neurons” in Scientific Reports (DOI: 10.1038/s41598-017-00676-w) Image: Micrographs of somatic, axon, and dendritic compartments of neurons cultured within a microfluidic chambers during maturation; see article for details.

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April 5, 2017: Mira Pronobis First Runner Up for Larry Sandler Award

Pronobis_MiraCongratulations to Mira Pronobis (PhD 2016, Mark Peifer lab) who was named runner up for the Larry Sandler Award. This award is given annually by the Genetics Society of America for the most outstanding dissertation in any area of Drosophila research internationally.

March 27, 2017: Kendall Lough awarded F31 fellowship

Lough_KendallKendall Lough (Scott Williams lab) was awarded an NRSA F31 fellowship from the National Institute of Dental and Craniofacial Research. Kendall is researching the role of nectin adhesion proteins and their downstream effector afadin in palate closure.

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March 27, 2017: Tim Dinh publishes paper in Scientific Reports

Dinh_2017Tim Dinh (Praveen Sethupathy lab) published an article titled “Comprehensive analysis of The Cancer Genome Atlas reveals a unique gene and non-coding RNA signature of fibrolamellar carcinoma” in Scientific Reports (DOI: 10.1038/srep44653) Image: Hierarchical clustering of fibrolamellar carcinoma, hepatocellular carcinoma, and cholangiocarcinoma samples in TCGA.; see article for details.

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March 9, 2017: Julie Korda Holsclaw publishes paper in Genetics

Korda_Holsclaw_2017Julie Korda Holsclaw (Jeff Sekelsky lab) published an article titled “Annealing of Complementary DNA Sequences During Double-Strand Break Repair in Drosophila Is Mediated by the Ortholog of SMARCAL1″ in Genetics (DOI: 10.1534/genetics.117.200238). Image: Reduction in SDSA in Marcal1 and BRCA2 mutants; see article for details.

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March 9, 2017: Rowan Beck publishes review in Current Diabetes Reports

Beck_RowanRowan Beck (Praveen Sethupathy and Mirek Styblo labs) published a review article titled, “Arsenic exposure and type 2 diabetes: MicroRNAs as mechanistic links?” in Current Diabetes Reports (DOI: 10.1007/s11892-017-0845-8).

 

 

March 9, 2017: Rowan Beck wins award for Society of Toxicology meeting

Beck_RowanCongratulations to Rowan Beck (Praveen Sethupathy and Mirek Styblo labs), who was awarded 1st prize for the Metals Specialty Section Graduate Student Awards for the annual Society of Toxicology meeting. Rowan’s poster was on her research into microRNAs as potential mediators of the effects of arsenicals on pancreatic beta cell function.

March 1, 2017: Carrie Wilczewski awarded F31 fellowship

WilczewskiCarrie Wilczewski (Frank Conlon lab) was awarded an NRSA F31 fellowship from the National Heart, Lung, and Blood Institute. The title of her project is “Transcriptional repression by the Nucleosome Remodeling and Deacetylase (NuRD) complex in cardiac development and human disease.

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February 16, 2017: Ann Emery publishes paper in Journal of Virology

Emery_2017Ann Emery (Ron Swanstrom lab) published an article titled “Characterizing HIV-1 splicing using next generation sequencing” in Journal of Virology (DOI:10.1128/JVI.02515-16). Image: Splicing in founder and transmittend HIV-1 (click to enlarge; see article for details).

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February 15, 2017: Greg Zapotoczny publishes paper in G3: Genes|Genomes|Genetics

Zapotoczny_2017Greg Zapotoczny (Jeff Sekelsky lab) published an article titled “Human cell assays for synthesis-dependent strand annealing and crossing over during double-strand break repair” in G3: Genes|Genomes|Genetics (DOI:10.1534/g3.116.037390). Image: U2OS cells expression GFP (crossover) or GFP and mCherry (non-crossover) after double-strand break repair; see article for details.

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January 22, 2017: Mira Pronobis publishes paper in Molecular Biology of the Cell

Pronobis_2017Mira Pronobis (Mark Peifer lab) published an article titled “Reconstituting regulation of the canonical Wnt pathway by engineering a minimal β-catenin destruction machine” in Molecular Biology of the Cell (DOI:10.1091/mbc.E16-07-0557). Image: Superesolution microscopy (SIM) showing assembly into supermolecular puncta of Axin alone, Axin plus APC or the a designed chimera; click to enlarge; see article for details.)

 

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January 18, 2017: Bailey Peck publishes paper in Journal of Biological Chemistry

Peck_2017Bailey Peck (Praveen Sethupathy lab) published an article titled “Functional transcriptomics in diverse intestinal epithelial cell types reveals robust microRNA sensitivity in intestinal stem cells to microbial status” in Journal of Biological Chemistry (DOI:10.1074/jbc.M116.770099). Bailey’s paper was featured in an article from the UNC Newsroom.  Image: Model of miR-375-3p-mediated effects of microbiota on intestinal epithelial stem cell proliferation; see article for details.

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January 9, 2017: Talia Hatkevich and Kathryn Kohl publish paper in Current Biology

hatkevich_2017Talia Hatkevich (Jeff Sekelsky lab) and Kathryn Kohl (former GMB student, currently Assistant Professor at Winthrop University) published an article titled “Bloom syndrome helicase promotes meiotic crossover patterning and homolog disjunction” in Current Biology (DOI:10.1016/j.cub.2016.10.055), highlighted in a Dispatch. GMB student Michaelyn Hartmann was a co-author. Image: Graphical abstract showing effects of Blm mutation on meiotic crossover patterning; click to magnify; see article for details.

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January 9, 2017: Mike Conlin awarded F31 fellowship

conlin_mikeMike Conlin (Dale Ramsden lab) was awarded an NRSA F31 fellowship from the National Cancer Institute. The title of his project is “Mechanism of Damage Tolerance by Nonhomologous End Joining.

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December 12, 2016: Christian Parobek publishes paper in PNAS

parobek_2016bChristian Parobek (Jonathon Juliano lab) published an article titled “Selective sweep suggests transcriptional regulation may underlie Plasmodium vivax resilience to malaria control measures in Cambodia” in Proceedings of the National Academy of Sciences (Early Edition). Image: Manhattan plot of sites under strong selection; see article for details.

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December 12, 2016: Christian Parobek publishes paper in Molecular Ecology Resources

parobek_2016aChristian Parobek (Jonathon Juliano lab) published an article titled “skelesim: an extensible, general framework for population genetic simulation in R” in Molecular Ecology Resources. Image: Output from skelesim simulations. See article for details.

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September 23, 2016: AMY GLADFELTER NAMED HHMI FACULTY SCHOLAR

Congratulationgladfelter-hhmi-for-webs to GMB faculty member Dr Amy Gladfelter (Department of Biology), who has been named a Howard Hughes Medical Institute (HHMI) Faculty Scholar. This designation is awarded to early-career scientists who have great potential to make unique contributions to their field. Dr. Gladfelter’s research focuses on how multinucleate cells are organized in time and space and how cells perceive their shape and use geometry to inform signaling and decision-making.  READ MORE >>

September 22, 2016: Catherine Fahey and Julia DiFiore publishes paper in Journal of Biological Chemistry

Catherine Fahey (Kim Rathmell and Ian Davis labs) and Julia DiFiore (Brian Strahl lab) published an article titled “Structure/function analysis of recurrent mutations in SETD2 reveals a critical and conserved role for a SET domain residue in maintaining protein stability and H3K36 trimethylation” in Journal of Biology Chemistry (online ahead of print). (Image: γH2AX foci after irradiation of HKC cells carrying wild-type or mutant SETD2; see article for details.)

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September 7, 2016: Taylor Penke publishes paper in Genes and Development

Penke2016Taylor Penke (Bob Duronio lab) published an article titled “Direct interrogation of the role of H3K9 in metazoan heterochromatin function” in Genes and Development 30: 1866-1880. (Image: Cover showing Drosophila polytene chromosome from an H3K9R mutant stained with antibody for H3K9me3; see article for details.)

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September 7, 2016: Aminah Wali publishes paper in PNAS

Wali2016Aminah Wali (Ian Davis lab) published an article titled “High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility” in Proceedings of the National Academy of Sciences 113: 3018-23. (Image: Heat map of normalized FAIRE enrichment; see article for details.)

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August 22, 2016: Nicole Tackmann publishes paper in Cancer Research

Tackmann_2016Nicole Tackmann (Yanping Zhang lab) published an article titled “RPL23 links oncogenic RAS signaling to p53-mediated tumor suppression” in Cancer Research (online ahead of print). (Image: Ki-67 staining of skin tumors in mice, showing the effect of Mdm2m/m genotype; see article for details.)

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August 22, 2016: Nicole Tackmann receives Horizon Award Fellowship from DoD

carlsonn_3.jpgNicole Tackmann (Yanping Zhang lab) has received a Horizon Award fellowship from the Department of Defense for her project titled, “Characterizing the Role of Hep27 in Liver and Colorectal Cancer Stress Tolerance.”

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August 15, 2016: Tamara Roman wins Cotterman Award for her Publication

Roman_TamaraCongratulations to Tamara Roman (Karen Mohlke lab), whose was selected as a winner of the Cotterman Award.  This award is given annually by the American Society of Human Genetics, which selects two articles published in the American Journal of Human Genetics in the previous year that best represent outstanding scientific contributions to the field of human genetics.  Tamara was honored for her paper titled “Multiple hepatic regulatory variants at the GALNT2 GWAS locus associated with high density lipoprotein cholesterol.” (American Journal of Human Genetics 97: 801-815).

August 15, 2016: Maren Cannon selected as finalist for the Charles J. Epstein Trainee Award for Excellence in Human Genetics Research

Cannon_MarenCongratulations to Maren Cannon (Karen Mohlke lab), who was selected as a finalist for the Charles J. Epstein Trainee Award for Excellence in Human Genetics Research. The American Society of Human Genetics honors excellence in trainee research through awards that recognize highly competitive abstracts submitted and presented at the ASHG annual meeting. Maren was honored for her abstract titled, “Cardiometabolic variants in adipose tissue ATAC-seq peaks at GWAS loci with coincident adipose tissue eQTLs.”

August 14, 2016: David Wyatt publishes paper in Molecular Cell

Untitled-2David Wyatt (Dale Ramsden lab) published an article titled “Essential roles for polymerase θ-mediated end joining in the repair of chromosome breaks” in Molecular Cell (online ahead of print). (Image: Schematic showing when theta-mediated end joining is important.)

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August 14, 2016: Noelle Romero publishes paper in Genetics

Figure 3newNoelle Romero (Steve Matson lab and Jeff Sekelsky lab) published an article titled “Biochemical activities and genetic functions of the Drosophila melanogaster Fancm helicase in DNA repair” in Genetics (online ahead of print). (Image: Mitotic crossovers in different Fancm mutants.)

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August 14, 2016: Stephen McDaniel publishes paper in Journal of Biological Chemistry

McDaniel_2016Steven McDaniel (Brian Strahl lab) published an article titled “Combinatorial histone readout by the dual plant homeodomain (PHD) fingers of Rco1 mediates Rpd3S chromatin recruitment and the maintenance of transcriptional fidelity” in Journal of Biological Chemistry 291: 14796-802. (Image: Model for how the PHD fingers in Rpd3S and Rpd3L engage chromatin.)

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June 15, 2016: Pedro Pozo awarded F31 fellowship

Pozo_PedroPedro Pozo (Jean Cook lab) was awarded an F31 fellowship from the National Institute of General Medical Sciences. The title of his project is “Elucidating Cdt1 function using naturally occurring disease-associated mutations.

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June 14, 2016: Bailey Peck publishes paper in Journal of Biological Chemistry

Bailey PeckPeck_2016 (Praveen Sethupathy lab) published an article titled “miR-30 family controls proliferation and differentiation of intestinal epithelial cell models by directing a broad gene expression program that includes SOX9 and the ubiquitin ligase pathway” in Journal of Biological Chemistry (online ahead of print). (Image: Conservation of predicted miR-30 binding sites in SOX9 3′ UTR.)

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June 1, 2016: Talia Hatkevich awarded F31 fellowship

Hatkevich_TaliaTalia Hatkevich (Jeff Sekelsky lab) was awarded an F31 fellowship from the National Institute of Aging. The title of her project is “Preventing Aneuploidy in Aging Oocytes: Investigating the effects
and mechanisms of cohesion enrichment in Drosophila melanogaster.

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June 1, 2016: Lyndsay Wylie awarded American Heart Association fellowship

Wylie_LyndsayCongratulations to Lyndsay Wylie (Vicki Bautch lab), who was awarded a grant from the American Heart Association.  Her project is titled “SMAD6 Function in Endothelial Cells.”

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April 23, 2016: Jordan Kardos publishes paper in JCI Insight

Kardos2016Jordan Kardos (William Kim lab) published an article titled “Claudin-low bladder tumors are immune infiltrated and actively immune suppressed” in JCI Insight. Image: Box plot of immune suppression gene signature z scores across the Pan-Cancer tumor types. See paper for details.

 

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April 23, 2016: Li-Chung Tsao publishes paper in Retrovirology

Su2016Li-Chung Tsao (Lishan Su lab) published an article titled “CCR5 interaction with HIV-1 Env contributes to Env-induced depletion of CD4 T cells in vitro and in vivo” in Retrovirology 13: 22. Image: FACS plots of CD4 and CD8 staining live CD3(+) T cells infected with a highly pathogenic HIV-1 isolate. See paper for details.

 

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April 23, 2016: Three GMB students receive Dissertation Completion Fellowships

Congratulations to Becky Bigler (Anne Taylor lab), Joy Meserve (Bob Duronio lab), and Danielle Rogers (Jeff Sekelsky lab) on being awarded Dissertation Completion Fellowships from The Graduate School at UNC.

March 3, 2016: Lauren Waldron Wasson publishes paper in Developmental Cell

Waldron_2016Lauren Waldron Wasson (Frank Conlon lab) published an article titled “The cardiac TBX5 interactome reveals a chromatin remodeling network essential for cardiac septation” in Developmental Cell 36: 262-275. Image: Low-magnification transverse section of a developing Xenopus heart; see article for complete figure and details.

 

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March 3, 2016: Josh Lawrimore’s research featured in The Pipettepen

chromoshakeJosh Lawrimore’s (Kerry Bloom lab) interdisciplinary research was described in an article on The Pipettepen titled Biology and Physics Meet in the Middle.
Image:  Figure from the chromoshake model of the yeast centromere. See Bloom lab website for details.

 

February 2, 2016: Tiki Hayes publishes paper in Cancer Cell

Hayes_2016Tiki Hayes (Channing Der lab) published an article titled “Long-term ERK inhibition in KRAS-mutant pancreatic cancer is associated with MYC degradation and senescence-like growth suppression” in Cancer Cell 29: 75-89. Image: Treated PANC253 tumors; see article for details.

 

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January 10, 2016: Dan Serber publishes paper in Biology of Reproduction

Serber_2015Dan Serber (Terry Magnuson lab) published an article titled “The mouse INO80 chromatin remodeling complex is an essential meiotic factor for spermatogenesis” in Biology of Reproduction (epub ahead of print). Image: unrepaired DNA breaks in Ino80cKO spermatocytes; see article for details.

 

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January 10, 2016: Christian Parobek publishes paper in Antimicrobial Agents and Chemotherapy

Parobek_2015bChristian Parobek (Jonathon Juliano lab) published an article titled “Next-Generation sequencing and comparative analysis of sequential outbreaks caused by multidrug-resistant Acinetobacter baumannii at a large academic burn center” in Antimicrobial Agents and Chemotherapy (online ahead of print). Image: Reconstruction of transmission chains for multi-drug resistant Acinetobacter baumannii outbreak isolates. See article for details.

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December 11, 2015: Tamara Roman publishes paper in American Journal of Human Genetics

revisedfigures_9_15_15.pptxTamara Roman (Karen Mohlke lab) published an article titled “Multiple hepatic regulatory variants at the GALNT2 GWAS locus associated with high-density lipoprotein cholesterol” in American Journal of Human Genetics 97: 801-15. Image: Transcription factor CEBPB binds differentially to the alleles of regulatory variant rs4846913; see article for details.

 

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December 2, 2015: Erin Borchardt publishes paper in RNA

Borchardt2015Erin Borchardt (Aravind Asokan lab) published an article titled “Controlling mRNA stability and translation with the CRISPR endoribonuclease Csy4” in RNA 21: 1921-30. Image: effects of wild-type (top) and mutant (bottom) Csy4 on gene expression; see article for details.

 

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December 2, 2015: Marni Siegel publishes paper in Molecular Cancer Therapeutics

Seigel2015 Marni Siegel (Carey Anders and Chuck Perou labs) published an article titled “Efficacy of carboplatin alone and in combination with ABT888 in intracranial murine models of BRCA-mutated and BRCA-wild-type triple-negative breast cancer” in Molecular Cancer Therapeutics 14: 920-30. (Image: expression patterns of tumors treated within the BRCA-mutant models; see article for details.)

 

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December 2, 2015: Tiki Hayes wins Graduate Fellow Award

Hayes_TikiCongratulations to Tiki Hayes (Channing Der lab), who won the Lineberger Comprehensive Cancer Center Graduate Fellow Award in Basic Sciences.

 

December 2, 2015: Kate Coleman wins Graduate Fellow Award

Congratulations to Kate Coleman (Jean Cook lab), who won the Lineberger Comprehensive Cancer Center Graduate Fellow Award in Basic Sciences.

 

October 7, 2015: Aziz Sancar wins Nobel Prize

AzizSancarSPOTgraphicCongratulations to Aziz Sancar, winner of the 2015 Nobel Prize in Chemistry. Aziz shares the award with Paul Modrich and Thomas Lindahl for groundbreaking studies of DNA repair mechanisms. Read more on the UNC website.

 

 

 

October 2, 2015: Claire Trincot awarded American Heart Association fellowship

Claire TrincotCongratulations to Claire Trincot (Kathleen Caron lab), who was awarded a grant from the American Heart Association.  Her project is titled “Cardioprotective effects of adrenomedullin in a model of myocardial infarction.”

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October 2, 2015: Mira Pronobis publishes paper in eLife

Pronobis2015Mira Pronobis (Mark Peifer lab) published an article titled “A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient β-catenin destruction” in eLife doi: 10.7554/eLife.08022. (Image: Superesolution microscopy (SIM) showing macromolecular complex between axin (magenta) and APC2 (green); see article for details.)

 

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August 20, 2015: Taylor Penke awarded F31 fellowship

Penke_TaylorTaylor Penke (Bob Duronio lab) was awarded an F31 fellowship from the National Institute of General Medical Sciences. The title of his project is “Investigating the role of histone modifications in heterochromatin formation“.

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August 20, 2015: Catherine Fahey awarded F30 fellowship

Fahey_CatherineCatherine Fahey (Kim Rathmell lab) was awarded an F30 fellowship from the National Cancer Institute. The title of her project is “The effect of cancer-associated SETD2 mutations on transcription and chromatin organization“.

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August 20, 2015: Joy Meserve publishes paper in Development

JMeserve2015oy Meserve (Bob Duronio lab) published an article titled “Scalloped and Yorkie are required for cell cycle re-entry of quiescent cells after tissue damage.” in Development 142: :2740-2751 (Image: Compensatory proliferation after induced cell death in the eye; see article for details.)

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July 28, 2015: Christian Parobek awarded F30 fellowship

Christian ParobekChristian Parobek (Jon Juliano lab) was awarded an F30 fellowship from the National Institute of Allergy and Infections Diseases. The title of his project is “Investigating the targets and strain specificity of antibodies against P. vivax”.

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July 15, 2015: Bailey Peck publishes paper in Inflammatory Bowel Diseases

Peck_2015Bailey Peck (Praveen Sethupathy lab) published an article titled “MicroRNAs classify different disease behavior phenotypes of Crohn’s disease and may have prognostic utility.” in Inflammatory Bowel Diseases (online ahead of print). (Image: Average miRNA expression in B3/penetrating class patient biopsies; see paper for full image and legend.)

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June 5, 2015: Kerry Dorr publishes paper in Development

Dorr-DevelopmentKerry Dorr (Frank Conlon lab) published an article titled “Casz1 is required for cardiomyocyte G1-to-S phase progression during mammalian cardiac development.” in Development 142: 2037-2047 (Image: Caz1 expression in the developing heart; see paper for full image and legend.)

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June 5, 2015: Luciana Leopold publishes paper in PNAS

Leopold-PNASLuciana Leopold (Shawn Ahmed lab) published an article titled “Lack of pairing during meiosis triggers multigenerational transgene silencing in Caenorhabditis elegans.” in Proceedings of the National Academy of Science 112: E2667-76. (Image: effects of mutations on transgenerational RNAe; see paper for full image and legend.)

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June 5, 2015: Diana Chong awarded American Heart Association fellowship

Chong_DianaCongratulations to Diana Chong (Vicki Bautch lab), who was awarded a grant from the American Heart Association.  Her project is titled “Analysis of Tortuous Vessel Formation and Sprouting”.

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May 28, 2015: Ann Emery awarded NRSA F31 fellowship

Emery_AnnCongratulations to Ann Emery (Ron Swanstrom lab), who was awarded an NRSA F31 predoctoral fellowship from the National Institute of Allergies and Infectious Diseases (NIAID) of the National Institutes of Health.  Ann’s project is titled “Quantification of HIV-1 splicing phenotypes and the role of RNA structure and splice regulator elements“.

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May 28, 2015: Kathryn Headley awarded NSF Graduate Research Fellowship

Kathryn HeadleyCongratulations to Kathryn Headley (Nate Hathaway lab), who was awarded a Graduate Research Fellowship from the National Science Foundation.  Kathryn’s project is titled, “Enhancing reactivation of stem cell factor Oct4 with novel small molecules“.

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May 8, 2015: GMB Students Participate in NC DNA Day

Canon_DNA_DayMore than two dozen GMB students participated in the 9th Annual North Carolina DNA Day by visiting state high schools to talk to students about DNA and science. An article, featuring GMB student Maren Canon (Karen Mohlke lab), was published on the UNC Healthcare website.

May 1, 2015: Giri Murlidharan publishes paper in Journal of Virology

Murlidharan_2015Giri Murlidharan (Aravind Asokan lab) published an article titled “Unique glycan signatures regulate adeno-associated virus tropism in the developing brain” in Journal of Virology 89:3976-87. (Image: localization of CBA protein introduced by AAV in primary astrocytes; see paper for full image and legend.)

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May 1, 2015: Esteban Terzo publishes paper in Molecular Biology of the Cell

Terzo_2015Esteban Terzo (Bob Duronio lab) published an article titled “Distinct self-interaction domains promote Multi Sex Combs accumulation in and formation of the Drosophila histone locus body” in Molecular Biology of the Cell 26:1559-74. (Image: co-localization of GFP-MXC and FLASH at the histone locus body; see paper for full image and legend.)

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April 15, 2015: NRSA T32 Training Grant Renewed for Years 41-45

The NNIGMSRSA T32 training grant that supports the Curriculum in Genetics and Molecular Biology was renewed by NIGMS. The proposal, submitted in January, 2014, received a priority score of 20 in the June study section. This grant, which has been funded since 1975, will continue to support training activities and contribute to the stipends of selected GMB students until 2020.

April 1, 2015: Bailey Peck awarded NRSA F31 fellowship

Peck_BaileyCongratulations to Bailey Peck (Praveen Sethupathy lab), who was awarded an NRSA F31 predoctoral fellowship from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health.  Bailey’s project is titled “Whole transcriptome analysis of distinct populations of the intestinal epithelium and its response to microbial presence“.

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April 1, 2015: Tangi Smallwood publishes paper in G3: Genes, Genomes, Genetics

Smallwood-G3Tangi Smallwood (Brian Bennett lab) published an article titled “High-resolution genetic mapping in the diversity outbred mouse population identifies Apobec1 as a candidate gene for atherosclerosis” published in G3: Genes, Genomes, Genetics 4: 2353-2363. (Image: Mapping of significant hits on Chromosome 9 for plasma triglyceride levels; see paper for full image and legend.)

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February 18, 2015: Maren Cannon awarded NRSA F31 fellowship

Cannon_MarenCongratulations to Maren Cannon (Karen Mohlke lab), who was awarded an NRSA F31 predoctoral fellowship from the National Heart, Lung, and Blood Institute of the National Institutes of Health.  Maren’s project is titled “Genetic and metabolic effects on ANGPTL8 expression and HDL-C metabolism“.

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February 2, 2015: John Runge receives McClendon-Thomas Award

Runge_JohnCongratulations to John Runge (Terry Magnuson lab), winner of the Bullit History of Medicine Club’s McClendon-Thomas Award. This award recognized scholarly excellence in the history of health sciences. John’s essay “Character Trials: Managing Epidemic Disease in the 19th Century American South” describes efforts to stop Yellow Fever from spreading across the South during Reconstruction, drawing parallels to the HIV/AIDS and Ebola outbreaks. John and his historical research were featured in the Vital Signs newsletter.

December 2, 2014: Julie Holsclaw awarded NRSA F31 fellowship

Julie_HolsclawCongratulations to Julie Holsclaw (Jeff Sekelsky lab), who was awarded an NRSA F31 predoctoral fellowship from the National Institute of General Medical Sciences of the National Institutes of Health.  Her project is titled “Determining the role of Blm and Marcal1 helicases in replication fork remodeling and progression“.

Please also see our page on Grants to GMB Students.

November 27, 2014: Christian Parobek awarded off-campus dissertation fellowship

Christian ParobekChristian Parobek (Jon Juliano lab) was awarded an Off-Campus Dissertation Research Fellowship by The Graduate School. Christian will work in Cambodia during Spring 2015 collecting mRNA from the malaria vector P. vivax for his dissertation research.

August 27, 2014: Crystal Waters publishes paper in Nature Communications

CrystFigure-7 (Ramsden)al Waters (Dale Ramsden lab) published an article titled “The fidelity of the ligation step determines how ends are resolved during nonhomologous end joining” published in Nature Communications 5: 4286. (Image: Model for organization of enzymatic steps during NHEJ.)

Please see our page on Publications by GMB Students for more.

August 26, 2014: Jennifer Kulzer wins Cotterman Award for her Publication

Jen Kulzer 2014Congratulations to Jennifer Kulzer (Karen Mohlke lab), whose was selected as a winner of the Cotterman Award.  This award is given annually by the American Society of Human Genetics, which selects two articles published in the American Journal of Human Genetics in the previous year that best represent outstanding scientific contributions to the field of human genetics.  Jennifer was honored for her paper titled “A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell” (Amer J Human Genetics 94: 186-97.

August 20, 2014: Laura Tollini publishes paper in Cancer Cell

Tollini_CancerCellLaura Tollini (Yanping Zhang lab) published an article titled “Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damage” published in Cancer Cell 26: 235-247. (Image: Mdm2:MdmX heterodimer regulation of p53.)

Please see our page on Publications by GMB Students for more.

August 12, 2014: Glenn Wozniak publishes paper in Genes and Development

Glenn WozWozniak figniak (Brian Strahl lab) published an article titled “Catalysis-dependent stabilization of Bre1 fine-tunes Histone H2B ubiquitylation to regulation gene transcription” published in Genes and Development 28: 1647-1652. (Image: Model for Bre1 function.)

Please see our page on Publications by GMB Students for more.

July 14, 2014: Alicia Greenwalt awarded NRSA F31 fellowship

Congratulations to Alicia Greenwalt (Cyrus Vaziri labGreenwalt_Alicia), who was awarded an NRSA F31 predoctoral fellowship from the National Cancer Institute of the National Institutes of Health.  Her project is titled “Targeting trans-lesion synthesis (TLS) for cancer therapy”.

June 24, 2014: Matt Simon publishes paper in Cell Reports

Simon_CellReportsMatt Simon (Shawn Ahmed lab) published an article titled “Reduced insulin/IGF-1 signaling restores germ cell immortality to Caenorhabditis elegans Piwi mutants.” published in Cell Reports 7: 762-773. (Image: Changes in expression of tandem repeat loci, genome-wide.)

Please see our page on Publications by GMB Students for more.

June 24, 2014: David Wyatt awarded American Heart Association fellowship

Wyatt_DavidCongratulations to David Wyatt (Dale Ramsden lab), who was awarded a grant from the American Heart Association.  His project is titled “Mechanisms and Requirements of Alternative End Joining”.

June 20, 2014: Seven students appointed to genetics training grant

Seven students were selected to appointment to the T32 training grant, now entering it’s 40th year of NIGMS funding. These students were chosen from 22 highly qualified applicants:

  • Salma Azam, lab of Chad Pecot
  • Mike Conlin, lab of Dale Ramsden
  • Philip Coryell, lab of Jeremy Purvis
  • Julia DiFiore, lab of Brian Strahl
  • Talia Hatkevich, lab of Jeff Sekelsky
  • David Lee, lab of Maura Calabrese
  • Katie Rehain, lab of Amy Shaub Maddox

 

April 25, 2014: Noelle Romero receives Royster Society Dissertation Completion Fellowship

Romero_NoelleCongratulations to Noelle Romero (labs of Steve Matson and Jeff Sekelsky), who was awarded a Royster Society of Fellows Dissertation Completion Fellowship from the UNC Graduate School for 2014-2015.

April 25, 2014: Lauren Wasson receives Dissertation Completion Fellowship

Wasson_LaurenCongratulations to Lauren Wasson (Frank Conlon lab), who was awarded a Dissertation Completion Fellowship from the UNC Graduate School for 2014-2015.

April 16, 2014: Bailey Peck publishes paper in Diabetes

Kurz 2013 figureBailey Peck (Praveen Sethupathy lab) is co-first author on an article titled “microRNA-29 fine-tunes the expression of key FOXA2-activated lipid metabolism genes and is dysregulated in animal models of insulin resistance and diabetes” published in Diabetes (published online ahead of print, April 2014). (Image: Schematic of the FOXA2:miR-29 regulatory circuit in the liver; see article for details.)

Please see our page on Publications by GMB Students for more.

April 16, 2014: Bob Duronio inducted into Frank Porter Graham Honor Society

Bob Duronio FPG inductionDr. Bob Duronio, Professor of Biology and Director of the Curriculum in Genetics and Molecular Biology from 2003 until 2012, was inducted into the Frank Porter Graham Honor Society, in recognition of his outstanding contributions to graduate education.

April 3, 2014: Casey Schmidt awarded NSF Graduate Research Fellowship

Casey SchmidtCongratulations to Casey Schmidt (Greg Matera lab), who was awarded a Graduate Research Fellowship from the National Science Foundation.  Casey’s project is titled, “Analyzing transcriptome changes in response to the loss of transcriptional regulators.”

Please also see our page on Grants to GMB Students.

April 3, 2014: Kristi Schaefer awarded NSF Graduate Research Fellowship

Kristi Schaefer

Congratulations to Kristi Schaefer (Mark Peifer lab), who was awarded a Graduate Research Fellowship from the National Science Foundation. Kristi’s project is titled, “Defining how the destruction complex is regulated and transfers beta-catenin to the E3 Ligase.”

Please also see our page on Grants to GMB Students.

March 9, 2014: Jennifer Kulzer publishes paper in American J. Human Genetics

Kulzer_AJHGJennifer Kulzer(Karen Mohlke lab) published a paper titled “A common functional regulatory variant at a type 2 diabetes locus upregulates ARAP1 expression in the pancreatic beta cell” in American Journal of Human Genetics (v. 94, pp 186-197). (Image: Association of SNPs with fasting proinsulin levels; see article for details.)

Please see our page on Publications by GMB Students for more.

March 9, 2014: Christian Parobek publishes paper in J. Clinical Microbiology

Parobek_JCMicroChristian Parobek (Jon Juliano lab) published a paper titled “A multilocus microsatellite genotyping array to investigate the genetic epidemiology of Pneumocystis jirovecii” in Journal of Clinical Microbiology (published ahead of print Feb 12). (Image: Potential mutational paths from haplotypes from Uganda, Spain, and San Francisco.)

Please see our page on Publications by GMB Students for more.

March 9, 2014: Kate Hacker publishes paper in Genome Research

Hacker Genome ResearchKate Hacker (Kim Rathmell lab) is co-first author on a paper titled “Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects” in Genome Research (v. 24, pp 241-250). (Image: H3K36me3 staining in clear cell renal carcinoma – normal kidney pairs; see article for details.)

March 9, 2014: Jeffrey Damrauer publishes paper in PNAS

JefDamrauer PNAS modelfrey Damrauer (Billy Kim lab) published a paper titled “Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology” in Proceedings of the National Academy of Sciences, USA (v. 111, pp 3110-3115). (Image: proposed model of urothelial tumorigenesis; see article for details.)

February 20, 2014: Mike Meers awarded NRSA F31 fellowship

Mike MeersCongratulations to Mike Meers (Greg Matera lab), who was awarded an NRSA F31 predoctoral fellowship from the National Cancer Institute of the National Institutes of Health.  His project is titled “Studying the role of H3K36 methylation in development and gene expression”.

February 3, 2014: Kathryn Kohl runner up for Larry Sandler Award

Congratulations to Kathryn Kohl (PhD 2013, Jeff Sekelsky lab) who was named runner up for the Larry Sandler Award. This award is given annually by the Genetics Society of America for the most outstanding dissertation in any area of Drosophila research.  This year there were 23 nominations from around the world.

December 10, 2013: Tikvah Hayes awarded NRSA F31

Hayes_TikiCongratulations to Tikvah Hayes (Channing Der lab), who was awarded an NRSA F31 predoctoral fellowship from the National Institutes of Health.  Tiki’s project is titled “Targeting K-RAS Effector Signaling for Pancreatic Cancer Treatment.”

October 3, 2013: Marta Charpentier and Laura Tollini win Kenan-Hobgood Award

Marta Charpentier (Frank Conlon lab) and Laura Tollini (Yanping Zhang lab) were awarded the 2013 Sarah Graham Kenan-Edwards Hobgood Award.  This honor is awarded each year to one or two outstanding students in the Curriculum in Genetics and Molecular Biology.

August 21, 2013: Joy Meserve awarded NRSA F31 fellowship

Joy MeserveCongratulations to Joy Meserve (Bob Duronio lab), who was awarded an NRSA F31 predoctoral fellowship from the National Institutes of Health.

May 30, 2013: Esteban Terzo awarded NRSA F31 fellowship

Esteban TerzoCongratulations to Esteban Terzo (Bob Duronio lab), who was awarded an NRSA F31 predoctoral fellowship from the National Institutes of Health.

May 15, 2013: Marta Charpentier gets cover of Developmental Cell

Charpentier_DevCell_coverCongratulations to Marta Charpentier (lab of Frank Conlon), first author of a publication in Developmental Cell, titled “CASZ1 promotes vascular assembly and morphogenesis through the direct regulation of an EGFL7/RhoA-mediated pathway.”  Marta’s work was featured as the cover image.

May 15, 2013: Nick Gomez receives travel award from AACR

Nick_GomezCongratulations to Nick Gomez (lab of Ian Davis), recipient of a 2013 American Association of Cancer Research Minority Scholar in Cancer Research Award for participation in the AACR Special Conference on Chromatin and Epigenetics in Cancer.

May 15, 2013: Kelsey Gray awarded NSF Graduate Research Fellowship

Kelsey_GrayCongratulations to Kelsey Gray (Greg Matera lab), who was awarded a Graduate Research Fellowship from the National Science Foundation.

May 15, 2013: Marta Charpentier receives Dissertation Completion Fellowship

Marta SzmacinskiCongratulations to Marta Charpentier (Frank Conlon lab), who was awarded a Dissertation Completion Fellowship from the UNC Graduate School for 2013-2014.

March 30, 2013: Danielle Rogers awarded NSF Graduate Research Fellowship

Congratulations to Danielle Rogers (labs ofJeff Sekelsky and Dorothy Erie), who was awarded a Graduate Research Fellowship from the National Science Foundation. Danielle’s project is Crossover formation in Drosophila: Elucidating the Structural Role of Meiotic Resolvases.”

February 20, 2013: Kate Coleman awarded NRSA F31 fellowship

Congratulations to Kate Coleman (Jean Cook lab), who was awarded an NRSA F31 predoctoral fellowship from the National Institutes of Health.

February 11, 2013: Kathryn Kohl receives Harold Weintraub Award

Congratulations to Kathryn Kohl (Jeff Sekelsky lab) for winning the Harold M. Weintraub Graduate Student Award, which recognizes outstanding achievement during graduate studies in the biological sciences. Recipients of this prestigious national award participate in a scientific symposium to be held this spring at the Fred Hutchinson Cancer Research Center in Seattle, WA.

January 2, 2013: GMB recognized by NIH for student diversity

The Curriculum in Genetics and Molecular Biology is listed on a site at the National Institute of General Medical Sciences for “NIGMS-Funded NRSA Training Programs with Notable Records of Diversity Recruitment and Retention“.

December 21, 2012: Kathryn Kohl publishes paper in Science

Congratulations to Kathryn Kohl for the recent publication of their paper in Science entitled “Evolution of an MCM Complex in Flies That Promotes Meiotic Crossovers by Blocking BLM Helicase”.