Our laboratory is interested in elucidating mechanisms of growth and differentiation. We are particularly interested in using the mouse as a model for the identification and functional characterization of genes and gene networks underlying individual variability. Concurrently, we are utilizing genomic and proteomic approaches to define the cellular consequences of individual variability at the molecular level and genetic engineering techniques to perform in vivo structure-function studies to validate the differences.

Our current biological foci are in three areas. A major emphasis is on defining the genetic and non-genetic factors contributing to colorectal cancer susceptibility. As part of this study, we are surveying the genetic variation in mouse strains contributing to colorectal cancer. Through these studies we have established the importance of specific molecules like the epidermal growth factor receptor for cancer formation. We have also begun a major project investigating gene networks influencing individual variability in gastrointestinal development. The third major emphasis is on the role of the epidermal growth factor receptor during placental development and its linkage with intra-uterine growth retardation.