We are interested in understanding how diverse cell types are produced during development from a single cell, the fertilized egg. We use primarily C. elegans embryos, because they allow us to address this issue using a large array of techniques, including live cell imaging, cell biology, forward and reverse genetics, molecular biology, biochemistry and direct manipulation of cells. Members of the lab are currently studying how asymmetric cell divisions are accomplished, how mitotic spindles are oriented in embryonic cells, how cells find their positions during development, and how RNA interference works.